L-selectin stimulates the neutral sphingomyelinase and induces release of ceramide.

@article{Brenner1998LselectinST,
  title={L-selectin stimulates the neutral sphingomyelinase and induces release of ceramide.},
  author={Brigit Brenner and Heike U. C. Grassm{\'e} and Christoph M{\"u}ller and Florian Lang and Christian Paul Speer and Erich Gulbins},
  journal={Experimental cell research},
  year={1998},
  volume={243 1},
  pages={123-8}
}
Selectins have been shown to be crucial in the rolling process of leukocytes during lymphocyte homing and in the early phase of inflammatory processes. Recently, we and others have shown that binding of L-selectin to its ligands correlates with a rapid induction of several intracellular signaling molecules, in particular, Src-like tyrosine kinases, MAP-kinases, Jun NH2-terminal kinase, the small G-proteins Ras and Rac, and a release of Ca2+ in leukocytes. Here, we demonstrate the activation of… CONTINUE READING

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