L-selectin mediates neutrophil rolling in inflamed venules through sialyl LewisX-dependent and -independent recognition pathways.

@article{Andrian1993LselectinMN,
  title={L-selectin mediates neutrophil rolling in inflamed venules through sialyl LewisX-dependent and -independent recognition pathways.},
  author={Ulrich H von Andrian and Joanne Chambers and Ellen Lakey Berg and Sara A. Michie and David Adam Brown and Dale Karolak and Lafeh Ramezani and Elaine M. Berger and Karl E. Arfors and Eugene C. Butcher},
  journal={Blood},
  year={1993},
  volume={82 1},
  pages={182-91}
}
The glycoprotein (GP) L-selectin initiates adhesive interactions between leukocytes and endothelial cells (EC). It functions as a lymphocyte-lectin homing receptor recognizing carbohydrate determinants of the peripheral lymph node addressing on high endothelial venules. It also mediates neutrophil rolling, the earliest interaction of neutrophils with acutely inflamed venules. Neutrophil L-selectin presents sialyl-LewisX (sLe(X)) as a ligand to P- and E-selectin in vitro, and we have proposed… CONTINUE READING

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