L-selectin ligation-induced CSF-1 gene transcription is regulated by AP-1 in a c-Abl kinase-dependent manner.

@article{Chen2008LselectinLC,
  title={L-selectin ligation-induced CSF-1 gene transcription is regulated by AP-1 in a c-Abl kinase-dependent manner.},
  author={Cuixia Chen and Xin Shang and Lingling Cui and Ting Xu and Jixian Luo and Xueqing Ba and Xianlu Zeng},
  journal={Human immunology},
  year={2008},
  volume={69 8},
  pages={501-9}
}
L-selectin is a cell adhesion molecule that plays an important role both in mediating the initial capture and subsequent rolling of leukocytes along the endothelial cells and in the signal transduction for leukocyte activation. In our previous studies, we reported that L-selectin ligation could increase macrophage colony-stimulating factor (CSF)-1 gene transcription, in which c-Abl acts as a crucial cytoplasmic kinase. Here we investigated the function of the nuclear c-Abl kinase in the CSF-1… CONTINUE READING

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