L-selectin defines a bone marrow analog to the thymic early T-lineage progenitor.

@article{Perry2004LselectinDA,
  title={L-selectin defines a bone marrow analog to the thymic early T-lineage progenitor.},
  author={S. Scott Perry and Hongfang Wang and L. Jeanne Pierce and Anne Marie Yang and Schickwann Tsai and Gerald J. Spangrude},
  journal={Blood},
  year={2004},
  volume={103 8},
  pages={2990-6}
}
The recent description of an early T-lineage progenitor (ETP) population in adult mouse thymus implies the presence of a bone marrow predecessor that has not yet been identified. Here we describe a Lin(Neg) Sca-1(Pos) c-kit(Hi) Thy-1.1(Neg) L-selectin(Pos) adult mouse bone marrow population that resembles the thymic ETP in both antigen expression phenotype and posttransplantation lineage potential. These cells produce wavelike kinetics of thymic seeding and reconstitute the irradiated thymus… CONTINUE READING

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