L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes.

@article{Wagner1998LselectinAB,
  title={L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes.},
  author={Norbert Wagner and J{\"u}rgen Loehler and Thomas F. Tedder and K. Rajewsky and Werner M{\"u}ller and Douglas A. Steeber},
  journal={European journal of immunology},
  year={1998},
  volume={28 11},
  pages={3832-9}
}
Mesenteric lymph nodes (MLN) drain the gut where nutritive antigens and pathogens are encountered by lymphocytes of the gut-associated lymphoid tissue. We sought to determine how lymphocytes enter the MLN by studying mice double deficient for beta7 integrins and L-selectin. beta7/L-selectin double-deficient lymphocytes did not migrate into MLN. Most importantly, MLN formation was drastically impaired in beta7/L-selectin double-deficient mice. Lymphocyte numbers in MLN from beta7/L-selectin… CONTINUE READING

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