L-selectin activates JNK via src-like tyrosine kinases and the small G-protein Rac.

@article{Brenner1997LselectinAJ,
  title={L-selectin activates JNK via src-like tyrosine kinases and the small G-protein Rac.},
  author={Birgit C Brenner and Sheila Weinmann and Heike U. C. Grassm{\'e} and Florian Lang and Otwin Linderkamp and Erich Gulbins},
  journal={Immunology},
  year={1997},
  volume={92 2},
  pages={214-9}
}
Selectin and alpha 4 beta 7-integrins have been shown to mediate transient leucocyte interactions with endothelial cells which is a crucial step in the initial immune response to pathogens. We have previously shown that stimulation of T lymphocytes via L-selectin results in activation of a signalling cascade from the L-selectin molecule via the tyrosine kinase p56lck and tyrosine phosphorylation of L-selectin to the stimulation of p21Ras and Rac proteins. In the present study we demonstrate… CONTINUE READING

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NFAT regulates CSF-1 gene transcription triggered by L-selectin crosslinking.

Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al • 2010
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