L-nitroarginine increases blood pressure in the rat.

  title={L-nitroarginine increases blood pressure in the rat.},
  author={Yuta Kobayashi and Katsumi Ikeda and Kazumasa Shinozuka and Yasuo Nara and Yukio Yamori and Kaoru Hattori},
  journal={Clinical and experimental pharmacology & physiology},
  volume={18 6},
1. Effects of administration of NG-nitro-L-arginine (NO2Arg), a guanidino nitroarginine derivative, for 1 week on blood pressure and some vascular responses of rats were studied. 2. A significant rise of the systolic blood pressure was observed after the administration of NO2Arg with food (0.023% in weight, about 2.8 mg of NO2Arg per rat per day). Relaxation by acetylcholine decreased markedly in ring preparations of the thoracic aorta of NO2Arg-treated rats. However, glyceryltrinitrate-induced… CONTINUE READING