L-methylfolate: a vitamin for your monoamines.
@article{Stahl2008LmethylfolateAV, title={L-methylfolate: a vitamin for your monoamines.}, author={Stephen M Stahl}, journal={The Journal of clinical psychiatry}, year={2008}, volume={69 9}, pages={ 1352-3 } }
Synthesis of the monoamine neurotransmitters serotonin, dopamine, and norepinephrine is regulated by L-methylfolate, a derivate of the vitamin folate.
57 Citations
Folate, vitamin B₁₂, and S-adenosylmethionine.
- MedicineThe Psychiatric clinics of North America
- 2013
Epigenetics and methylomics in psychiatry.
- Psychology, BiologyThe Journal of clinical psychiatry
- 2009
Not all inherited traits, including psychiatric disorders, are due to changes in the DNA sequence of genes, in fact, many characteristics of cells are due instead to the selective activating and silencing of genes in a dynamic process known as epigenetics.
Folate in depression: efficacy, safety, differences in formulations, and clinical issues.
- Psychology, MedicineThe Journal of clinical psychiatry
- 2009
Several forms of folate appear to be safe and efficacious in some individuals with major depressive disorder, but more information is needed about dosage and populations most suited to folate therapy.
Folates and S-Adenosylmethionine for Major Depressive Disorder
- PsychologyCanadian journal of psychiatry. Revue canadienne de psychiatrie
- 2012
Although further randomized controlled trials in this area appear warranted, SAMe and L-methylfolate may represent a useful addition to the AD armamentarium and appear to be efficacious and well tolerated in reducing depressive symptoms.
Enhancement of recovery from mental illness with l-methylfolate supplementation.
- Psychology, MedicinePerspectives in psychiatric care
- 2018
People suffering from depression, schizophrenia, and dementia often have measurably lower levels of serum folate compared to people not experiencing psychiatric disorders. Augmentation of SSRI and…
Vitamin B Supplementation: What's the Right Choice for Your Patients?
- Medicine, PsychologyJournal of psychosocial nursing and mental health services
- 2017
Exploring the conversion of folate/folic acid into L-methylfolate and the various polymorphisms of the MTHFR gene and examining the B vitamins associated with the treatment of psychiatric symptoms will further allow nurses to comprehensively treat their patients with the appropriate B vitamins.
[Folates in the treatment of depression].
- Psychology, MedicineFortschritte der Neurologie-Psychiatrie
- 2014
The evidence for L-methylfolate and folic acid as antidepressive agents in depression is reviewed and their clinical use is discussed.
Impact of Supplementation and Nutritional Interventions on Pathogenic Processes of Mood Disorders: A Review of the Evidence
- PsychologyNutrients
- 2021
This narrative review was conducted using searches of the PubMed/Medline and Google Scholar databases from inception to November 2019. Clinical trials and relevant articles were identified by…
Good, better, best: clinical scenarios for the use of L-methylfolate in patients with MDD
- Medicine, PsychologyCNS Spectrums
- 2019
Recent advances in the pathophysiology of major depressive disorder as it pertains to folate and associated biomarkers are highlighted and the profiles of patients with depression who could benefit most from supplemental use of L-methylfolate are established.
References
SHOWING 1-7 OF 7 REFERENCES
The effect of tetrahydrofolate on tetrahydrobiopterin metabolism.
- Biology, MedicineJournal of mental deficiency research
- 1986
Patients with senile dementia could possibly be benefited by the administration of 5-methyltetrahydrofolate and vitamin B12, which appear to be required for the biosynthesis of tetRahydrobiopterin.
Novel Therapeutics for Depression: L-methylfolate as a Trimonoamine Modulator and Antidepressant-Augmenting Agent
- PsychologyCNS Spectrums
- 2007
The putative mechanism of action of MTHF as an augmenting agent to antidepressants is that it acts as a trimonoamine modulator (TMM), enhancing the synthesis of the three monoamines: dopamine (DA), norepinephrine (NE), and serotonin (5-HT), resulting in a boost to the efficacy of antidepressants.
Folate deficiency, biopterin and monoamine metabolism in depression.
- BiologyPsychological medicine
- 1992
Seven (21%) of 34 patients with a severe DSM-III diagnosis of major depression had red-cell folate levels below 150 ng/ml. This subgroup with folate deficiency had significantly lower CSF…
Folic acid: neurochemistry, metabolism and relationship to depression
- PsychologyHuman psychopharmacology
- 2004
The few studies available suggest folic acid has either antidepressant properties or can act as an augmenting agent for standard antidepressant treatment, although there is substantial evidence of the association between depressive disorder (particularly severe depression) and low folic Acid levels.
Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review.
- PsychologyAmerican journal of epidemiology
- 2007
An association between the MTHFR C677T variant and depression, schizophrenia, and bipolar disorder is demonstrated, raising the possibility of the use of folate in treatment and prevention.
Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity
- PsychologyJournal of Epidemiology and Community Health
- 2007
There is accumulating evidence that low folate status is associated with depression and definitive randomised-controlled trials to test the therapeutic benefit of folate are required to confirm or refute a causal relationship.
The relationship between brain folate and monoamine metabolism
- Botez MI, Reynolds EH, eds. Folic Acid in Neurology, Psychiatry and Internal Medicine
- 1979