L-methionine augments mammalian myocardial contraction by sensitizing the myofilament to Ca2+.

@article{Kihara1995LmethionineAM,
  title={L-methionine augments mammalian myocardial contraction by sensitizing the myofilament to Ca2+.},
  author={Yasuyuki Kihara and Moriaki Inoko and Shigetake Sasayama},
  journal={Circulation research},
  year={1995},
  volume={77 1},
  pages={80-7}
}
L-Methionine is an essential amino acid that has been reported to have a potent positive inotropic effect on the mammalian myocardium. We studied the mechanisms of the inotropic effect in ventricular myocardium from the rabbit. In the isolated coronary-perfused whole heart, L-methionine in a millimolar range exerted concentration-dependent positive inotropic effects on the isovolumic left ventricle, which were associated with negative lusitropic effects (prolonged time course of relaxation… CONTINUE READING