L-methionine-DL-sulfoximine induces massive efflux of glutamine from cortical astrocytes in primary culture.

@article{Albrecht1990LmethionineDLsulfoximineIM,
  title={L-methionine-DL-sulfoximine induces massive efflux of glutamine from cortical astrocytes in primary culture.},
  author={Jan Albrecht and M D Norenberg},
  journal={European journal of pharmacology},
  year={1990},
  volume={182 3},
  pages={587-9}
}
L-Methionine-DL-sulfoximine (MSO) is a potent convulsant which metabolically and morphologically primarily affects astroglia, and the links between the gliotoxic and neurophysiological effects of MSO are not clear. A 5 min treatment with 3 mM MSO increased the rate of efflux of newly loaded radiolabelled glutamine (Gln) from rat cortical astrocytes in primary culture to more than 400% of the basal efflux. MSO did not affect the efflux of the neurotransmitter amino acids GABA or D-aspartate (a… CONTINUE READING