L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists.

Abstract

Moderate hyperhomocysteinemia is associated with several diseases, including coronary artery disease, stroke, Alzheimer's disease, schizophrenia, and spina bifida. However, the mechanisms for their pathogenesis are unknown but could involve the interaction of homocysteine or its metabolites with molecular targets such as neurotransmitter receptors, channels… (More)

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Cite this paper

@article{Shi2003LhomocysteineSA, title={L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists.}, author={Qi Shi and Jason E. Savage and Sandra J. Hufeisen and Laura Rauser and Ewa Grajkowska and Paul R Ernsberger and Jarda T. Wroblewski and Joseph H. Nadeau and Bryan L. Roth}, journal={The Journal of pharmacology and experimental therapeutics}, year={2003}, volume={305 1}, pages={131-42} }