L-histidinol improves the selectivity and efficacy of alkylating agents and daunomycin in mice with P388 leukaemia.

@article{Warrington1989LhistidinolIT,
  title={L-histidinol improves the selectivity and efficacy of alkylating agents and daunomycin in mice with P388 leukaemia.},
  author={Robert C. Warrington and Wei D. Fang},
  journal={British Journal of Cancer},
  year={1989},
  volume={60},
  pages={652 - 656}
}
DBA/2J mice bearing a clonal isolate of the transplantable murine lymphocytic leukaemia line P388 were used to examine the effects of L-histidinol on the antitumour activity of three alkalyating agents (bis-chloroethylnitrosourea (BCNU), cis-diamminedichloroplatinum (II) (cisDDP) and cyclophosphamide) and the antitumour antibiotic daunomycin. [] Key Result Single, combined treatments with L-histidinol and either BCNU or cisDDP, at doses of the alkylating agents which were ineffective when used alone, were…
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