L-dopa therapy of uremic and idiopathic restless legs syndrome: a double-blind, crossover trial.

@article{Trenkwalder1995LdopaTO,
  title={L-dopa therapy of uremic and idiopathic restless legs syndrome: a double-blind, crossover trial.},
  author={C. Trenkwalder and K. Stiasny and T. Pollm{\"a}cher and T. Wetter and J. Schwarz and R. Kohnen and J. Kazenwadel and H. Kr{\"u}ger and S. Ramm and M. K{\"u}nzel},
  journal={Sleep},
  year={1995},
  volume={18 8},
  pages={
          681-8
        }
}
We report the effects of a single bedtime dose of L-dopa 100-200 mg on sleep quality, frequency of periodic leg movements (PLM) and daily living in patients with idiopathic and uremic restless legs syndrome (RLS). Seventeen patients with idiopathic and 11 with uremic (on continuous hemodialysis) RLS were evaluated comparatively by polysomnography, actigraphy and subjective ratings in a randomized, controlled and double-blind crossover trial with L-dopa and placebo for 4 weeks each… Expand
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