L-dopa increases α-synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro.

@article{Schmitt2015LdopaI,
  title={L-dopa increases α-synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro.},
  author={Ina Schmitt and Oliver Kaut and Hassan Khazneh and Laura deBoni and Ashar Ahmad and D. Berg and Christine Klein and Holger Fr{\"o}hlich and U. W{\"u}llner},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2015},
  volume={30 13},
  pages={1794-801}
}
BACKGROUND Increasing gene dosages of α-synuclein induce familial Parkinson's disease (PD); thus, the hypothesis has been put forward that regulation of gene expression, in particular altered α-synuclein gene methylation, might be associated with sporadic PD and could be used as a biological marker. METHODS We performed a thorough analysis of α-synuclein methylation in bisulfite-treated DNA from peripheral blood of 490 sporadic PD patients and 485 healthy controls and in addition analyzed the… CONTINUE READING
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