L-dopa cytotoxicity to PC12 cells in culture is via its autoxidation.

  title={L-dopa cytotoxicity to PC12 cells in culture is via its autoxidation.},
  author={Adnan Basma and Erick J. Morris and William J. Nicklas and Herbert M Geller},
  journal={Journal of neurochemistry},
  volume={64 2},
The mechanism of cytotoxicity of L-DOPA was studied in the rat pheochromocytoma PC12 cell line. The cytotoxicity of L-DOPA to PC12 cells was time and concentration dependent. Carbidopa, which inhibited the conversion of L-DOPA to dopamine, did not protect against L-DOPA cytotoxicity in PC12 cells. Furthermore, clorgyline, a selective inhibitor of monoamine oxidase type A, and pargyline, an inhibitor of both monoamine oxidase types A and B, both did not have an effect on L-DOPA toxicity. These… CONTINUE READING


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