L-dihydroxyphenylserine (Droxidopa) in the treatment of orthostatic hypotension
@article{Mathias2008LdihydroxyphenylserineI, title={L-dihydroxyphenylserine (Droxidopa) in the treatment of orthostatic hypotension}, author={Christopher J. Mathias}, journal={Clinical Autonomic Research}, year={2008}, volume={18}, pages={25-29} }
Neurogenic orthostatic hypotension is a cardinal feature of generalised autonomic failure and commonly is the presenting sign in patients with primary autonomic failure. Orthostatic hypotension can result in considerable morbidity and even mortality and is a major management problem in disorders such as pure autonomic failure, multiple system atrophy and also in Parkinson’s disease. Treatment is ideally two pronged, using non-pharmacological and pharmacological measures.Drug treatment ideally…
73 Citations
Droxidopa for the treatment of neurogenic orthostatic hypotension in neurodegenerative diseases
- MedicineExpert opinion on pharmacotherapy
- 2019
The authors review the effects of droxidopa in NOH with a focus on the neurodegenerative diseases PD, MSA, and pure autonomic failure (PAF, where results appear essentially similar) and indicates a positive yet short-lasting effect of the drug on OH Questionnaire composite score, light-headedness/dizziness score, and standing BP during the first two treatment-weeks.
L-DOPS and the treatment of neurogenic orthostatic hypotension
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- 2013
This review includes Phase II and III clinical trials undertaken that have examined the safety, efficacy and tolerability of DOPS in the treatment of neurogenic orthostatic hypotension.
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- Medicine
- 2014
Results from a few small and short placebo-controlled trials and clinical studies in neurogenic OH showed significant reductions in the manometric drop of blood pressure after posture changes or meals, but larger Phase III studies suggest a positive effect of the drug on dizziness.
Droxidopa | MedChemExpress
- Biology
- 2019
The acute administration of droxidopa in PVL and BDL rats caused a significant and maintained increase in arterial pressure and mesenteric arterial resistance, with a significant decrease of mesenterIC arterial and portal blood flow, without changing portal pressure and renal blood flow.
Orthostatic hypotension in Parkinson's disease
- Medicine, Biology
- 2013
The most important unanswered questions about PD-related OH, which may be the result of pre- and post-ganglionic adrenergic denervation or cognitive dysfunction, are discussed.
New Developments in the Management of Neurogenic Orthostatic Hypotension
- Medicine, BiologyCurrent Cardiology Reports
- 2014
Droxidopa was approved by the FDA in 2014 for the treatment of neurogenic OH associated with primary autonomic neuropathies including Parkinson disease, multiple system atrophy, and pure autonomic failure, in an attempt to provide a practical guide to its management.
Rascol , Olivier Emerging drugs for autonomic dysfunction in Parkinson ' s disease
- Medicine
- 2013
Evidence about the efficacy and safety of available treatments for autonomic dysfunction and potential targets for upcoming therapies are discussed, and preliminary evidence suggesting that fludrocortisone, domperidone, droxidopa or fipamezole may be effective for the treatment of orthostatic hypotension is suggested.
Emerging drugs for autonomic dysfunction in Parkinson's disease
- MedicineExpert opinion on emerging drugs
- 2013
Sound clinical trials are needed in order to allow firm evidence-based recommendations about these treatments, including BTX or behavioral therapy for urinary incontinence and lubiprostone and probiotics for constipation.
Diagnosis and Treatment of Orthostatic Hypotension in Parkinson's Disease
- Medicine, Biology
- 2013
The key physiopathological aspect of OH is an altered baroreflex function resulting from cardiac and vascular sympathetic denervation, which can be aggravated by heat, alcohol consumption or by drug treatments, such as antihypertensives, dopamine agonists or amantadine.
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