L-dihydroxyphenylserine (Droxidopa): a new therapy for neurogenic orthostatic hypotension

  title={L-dihydroxyphenylserine (Droxidopa): a new therapy for neurogenic orthostatic hypotension},
  author={Horacio Kaufmann},
  journal={Clinical Autonomic Research},
Neurogenic orthostatic hypotension results from failure to release norepinephrine, the neurotransmitter of sympathetic postganglionic neurons, appropriately upon standing. In double blind, cross over, placebo controlled trials, administration of droxidopa, a synthetic amino acid that is decarboxylated to norepinephrine by the enzyme l-aromatic amino acid decarboxylase increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability in patients… CONTINUE READING