L-carnitine supplementation for the management of fatigue in patients with cancer: an eastern cooperative oncology group phase III, randomized, double-blind, placebo-controlled trial.

@article{Cruciani2012LcarnitineSF,
  title={L-carnitine supplementation for the management of fatigue in patients with cancer: an eastern cooperative oncology group phase III, randomized, double-blind, placebo-controlled trial.},
  author={Ricardo Alberto Cruciani and Jenny J Zhang and Judith B. Manola and David Cella and Bilal Ansari and Michael J. Fisch},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2012},
  volume={30 31},
  pages={
          3864-9
        }
}
  • R. CrucianiJenny J Zhang M. Fisch
  • Published 1 November 2012
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
PURPOSE L-carnitine, a popular complementary and alternative medicine product, is used by patients with cancer for the treatment of fatigue, the most commonly reported symptom in this patient population. The purpose of this study was to determine the efficacy of L-carnitine supplementation as a treatment for fatigue in patients with cancer. PATIENTS AND METHODS In this double-blind, placebo-controlled trial, patients with invasive malignancies and fatigue were randomly assigned to either 2 g… 

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References

SHOWING 1-10 OF 20 REFERENCES

l‐Carnitine Supplementation for the Treatment of Fatigue and Depressed Mood in Cancer Patients with Carnitine Deficiency: A Preliminary Analysis

Preliminary data of an open‐label, dose‐finding study to determine safety and maximally tolerated dose (MTD) of 1 week of l‐carnitine supplementation in cancer patients with fatigue and carnitine deficiency are presented.

Potential role of levocarnitine supplementation for the treatment of chemotherapy-induced fatigue in non-anaemic cancer patients

In selected patients, levocarnitine supplementation may be effective in alleviating chemotherapy-induced fatigue, and this compound deserves further investigations in a randomised, placebo-controlled study.

Randomized phase III clinical trial of five different arms of treatment in 332 patients with cancer cachexia.

The most effective treatment in terms of all three primary efficacy endpoints and the secondary endpoints appetite, IL-6, GPS, and ECOG PS score was the combination regimen that included all selected agents.

Alterations of serum and urinary carnitine profiles in cancer patients: hypothesis of possible significance.

The increased clearance of acylcarnitine and excretion of large amounts of AIAC are proposed to be a response to chemotherapy and represent a loss of energy to the cancer patient.

Carnitine Administration Reduces Cytokine Levels, Improves Food Intake, and Ameliorates Body Composition in Tumor-Bearing Rats

It is suggested that carnitine may ameliorate cancer anorexia–cachexia, via reduction of the inflammatory status of MCA-sarcoma-bearing rats.

L-carnitine--metabolic functions and meaning in humans life.

It is suggested that continued studies are required before L-carnitine administration could be recommended as a routine procedure in the noted disorders, and further research is warranted in order to evaluate the biochemical, pharmacological, and physiological determinants of the response to carnitine supplementation.

The rapid assessment of fatigue severity in cancer patients

The Brief Fatigue Inventory was developed for the rapid assessment of fatigue severity for use in both clinical screening and clinical trials.