L-carnitine reduces doxorubicin-induced apoptosis through a prostacyclin-mediated pathway in neonatal rat cardiomyocytes.

  title={L-carnitine reduces doxorubicin-induced apoptosis through a prostacyclin-mediated pathway in neonatal rat cardiomyocytes.},
  author={Hung-Hsin Chao and Ju-Chi Liu and Hong-jye Hong and Jia-Wei Lin and Cheng-hsien Chen and Tzu-Hurng Cheng},
  journal={International journal of cardiology},
  volume={146 2},
BACKGROUND Clinical use of doxorubicin is greatly limited by its severe cardiotoxic side effects. L-carnitine is a vitamin-like substance which has been successfully used in many cardiomyopathies, however, the intracellular mechanism(s) remain unclear. The objective of this study was set to evaluate the protective effect of L-carnitine on doxorubicin-induced cardiomyocyte apoptosis, and to explore its intracellular mechanism(s). METHODS Primary cultured neonatal rat cardiomyocytes were… CONTINUE READING
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