L-carnitine protects neurons from 1-methyl-4-phenylpyridinium-induced neuronal apoptosis in rat forebrain culture.

@article{Wang2007LcarnitinePN,
  title={L-carnitine protects neurons from 1-methyl-4-phenylpyridinium-induced neuronal apoptosis in rat forebrain culture.},
  author={Cheng Wang and Natalya Sadovova and Haitham Kareem Ali and Helen Duhart and Xin Fu and Xuejing Zou and Tucker A. Patterson and Zbigniew K. Binienda and Ashraf Virmani and Merle G. Paule and William Slikker and S. F Ali},
  journal={Neuroscience},
  year={2007},
  volume={144 1},
  pages={46-55}
}
1-Methyl-4-phenylpyridinium ion (MPP+), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with an elevation of intracellular reactive oxygen species (ROS) and apoptosis. L-carnitine plays an integral role in attenuating the brain injury associated with mitochondrial neurodegenerative disorders. The present study investigates the effects of L-carnitine against the toxicity of MPP+ in rat forebrain primary… CONTINUE READING

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