L-carnitine effect on plasma lipoproteins of hyperlipidemic fat-loaded rats

@article{Maccari2006LcarnitineEO,
  title={L-carnitine effect on plasma lipoproteins of hyperlipidemic fat-loaded rats},
  author={Franco Maccari and A. Arseni and Piero Chiodi and Maria Teresa Ramacci and Luciano Angelucci and W. C. Hulsmann},
  journal={Lipids},
  year={2006},
  volume={22},
  pages={1005-1008}
}
The effect of oral L-carnitine administration to rats fed olive oil has been studied. Carnitine significantly decreased triglyceride, cholesterol and phospholipid levels. Particularly, the levels of chylomicron and very low density lipoproteins in the blood were lowered. Low density lipoprotein levels were not affected, and high density lipoproteins were found to be decreased by 20%. Because carnitine did not change the composition of chylomicron and very low density lipoproteins fraction or… 

Effects of Oral L-carnitine and DL-carnitine Supplementation on Alloxan-Diabetic Rats

The reduction of blood triacylglycerol obtained with carnitine supplementation in the diabetic rats did not depend on an amelioration in the glycemia and was mediated partly at least by an increment of serum and tissue concentrations of FC and TC.

Effect of L-Carnitine on Insulin Sensitivity and Responsiveness in Skeletal Muscle, Adipose tissue and Hepatic tissues

LC increased plasma FFA level and potentiated the effect of insulin on glucose uptake in EFP and hemidiaphragm, and decreased hepatic insulin sensitivity and responsivity and enhanced the suppressive effect ofulin on FFA release from different peripheral tissues.

L-CARNITINE-INDUCED MODULATION OF PLASMA FATTY ACIDS METABOLISM IN HYPERLIPIDEMIC RABBITS

It is concluded that Lcarnitine, in this experimental model, induces an improved lipoprotein metabolism.

Acetyl-l-carnitine supplementation restores decreased tissue carnitine levels and impaired lipid metabolism in aged rats Published, JLR Papers in Press, January 1, 2004. DOI 10.1194/jlr.M300425-JLR200

Results indicate that chronic ALCAR supplementation reverses the age-associated changes in lipid metabolism and decreases the cholesterol content and cholesterol-phospholipid ratio in the brain tissues of aged rats.

Effect of dietary lipid, carnitine and exercise on lipid profile in rat blood, liver and muscle.

Results from the present study showed that the intake of HF diet significantly increased the plasma and tissue lipid profile and MUFA-rich diet or carnitine supplementation and/or exercise may ameliorate the deleterious effects of HF.

Effects of L-Carnitine on the Formation of Fatty Acid Ethyl Esters in Brain and Peripheral Organs after Short-Term Ethanol Administration in Rat

Evidence that fatty acid ethyl esters could be mediators involved in the production of alcohol-dependent syndromes is supported and administration of L-carnitine greatly reduces these metabolic abnormalities supporting its potential usefulness as a pharmacological tool in alcoholism management.

Effects of Acetyl-L-Carnitine on the Formation of Fatty Acid Ethyl Esters in Brain and Peripheral Organs after Short-Term Ethanol Administration in Rat

Administration of acetyl-L-carnitine greatly reduced the metabolic abnormalities due to non-oxidative ethanol metabolism, through an increment in lipid metabolism/turnover and by the modulation of the activities of enzymes associated with FAEE synthesis.

Effects of L-carnitine and iron diet supplementations on growth performance, carcass characteristics and blood metabolites in fattening pigs

The results suggest the more effective outcomes can be reached when L-carnitine+Fe rather than only L- c Carnitine is used in diets, which increased the growth performance of growing pigs and increased the Fe content in the blood serum and the longissimus dorsi muscle of pigs.

Comparative acute effects of l-carnitine and dl-carnitine on hepatic catabolism of l-alanine and l-glutamine in rats.

The results showed a different acute effect of LCT and DLC on the activation of hepatic gluconeogenesis and ureagenesis promoted by l-glutamine, reinforcing the idea that DLC could not replace LCT.

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The addition of dl-carnitine to various types of particulate liver preparations resulted in augmented oxidation of labeled palmitate and stearate. In contrast, carnitine exerted little if any effec...