L-carnitine effect on plasma lipoproteins of hyperlipidemic fat-loaded rats

  title={L-carnitine effect on plasma lipoproteins of hyperlipidemic fat-loaded rats},
  author={Franco Maccari and A. Arseni and Piero Chiodi and Maria Teresa Ramacci and Luciano Angelucci and W. C. Hulsmann},
The effect of oral L-carnitine administration to rats fed olive oil has been studied. Carnitine significantly decreased triglyceride, cholesterol and phospholipid levels. Particularly, the levels of chylomicron and very low density lipoproteins in the blood were lowered. Low density lipoprotein levels were not affected, and high density lipoproteins were found to be decreased by 20%. Because carnitine did not change the composition of chylomicron and very low density lipoproteins fraction or… 

Effects of Oral L-carnitine and DL-carnitine Supplementation on Alloxan-Diabetic Rats

The reduction of blood triacylglycerol obtained with carnitine supplementation in the diabetic rats did not depend on an amelioration in the glycemia and was mediated partly at least by an increment of serum and tissue concentrations of FC and TC.

Effect of L-Carnitine on Insulin Sensitivity and Responsiveness in Skeletal Muscle, Adipose tissue and Hepatic tissues

LC increased plasma FFA level and potentiated the effect of insulin on glucose uptake in EFP and hemidiaphragm, and decreased hepatic insulin sensitivity and responsivity and enhanced the suppressive effect ofulin on FFA release from different peripheral tissues.


It is concluded that Lcarnitine, in this experimental model, induces an improved lipoprotein metabolism.

Acetyl-l-carnitine supplementation restores decreased tissue carnitine levels and impaired lipid metabolism in aged rats Published, JLR Papers in Press, January 1, 2004. DOI 10.1194/jlr.M300425-JLR200

Results indicate that chronic ALCAR supplementation reverses the age-associated changes in lipid metabolism and decreases the cholesterol content and cholesterol-phospholipid ratio in the brain tissues of aged rats.

Effect of dietary lipid, carnitine and exercise on lipid profile in rat blood, liver and muscle.

Results from the present study showed that the intake of HF diet significantly increased the plasma and tissue lipid profile and MUFA-rich diet or carnitine supplementation and/or exercise may ameliorate the deleterious effects of HF.

Effects of L-Carnitine on the Formation of Fatty Acid Ethyl Esters in Brain and Peripheral Organs after Short-Term Ethanol Administration in Rat

Evidence that fatty acid ethyl esters could be mediators involved in the production of alcohol-dependent syndromes is supported and administration of L-carnitine greatly reduces these metabolic abnormalities supporting its potential usefulness as a pharmacological tool in alcoholism management.

Effects of Acetyl-L-Carnitine on the Formation of Fatty Acid Ethyl Esters in Brain and Peripheral Organs after Short-Term Ethanol Administration in Rat

Administration of acetyl-L-carnitine greatly reduced the metabolic abnormalities due to non-oxidative ethanol metabolism, through an increment in lipid metabolism/turnover and by the modulation of the activities of enzymes associated with FAEE synthesis.

Effects of L-carnitine and iron diet supplementations on growth performance, carcass characteristics and blood metabolites in fattening pigs

The results suggest the more effective outcomes can be reached when L-carnitine+Fe rather than only L- c Carnitine is used in diets, which increased the growth performance of growing pigs and increased the Fe content in the blood serum and the longissimus dorsi muscle of pigs.

Comparative acute effects of l-carnitine and dl-carnitine on hepatic catabolism of l-alanine and l-glutamine in rats.

The results showed a different acute effect of LCT and DLC on the activation of hepatic gluconeogenesis and ureagenesis promoted by l-glutamine, reinforcing the idea that DLC could not replace LCT.



Role of carnitine in hepatic ketogenesis.

The findings suggest that the increased fatty acid flux through the carnitine acyltransferase reaction brought about by glucagon excess, with or without insulin deficiency, is mediated, at least in part, by elevation in the liver carnite concentration.

Sex differences in hepatic uptake of long chain fatty acids in single-pass perfused rat liver.

In the intact liver, as in isolated hepatocytes, there are profound sex differences in the uptake of long chain fatty acids, which may account in part for the observed sex steroid effects on hepatic triglyceride biosynthesis and VLDL production.

Systemic carnitine deficiency--a treatable inherited lipid-storage disease presenting as Reye's syndrome.

Prolonged treatment with oral carnitine over a six-month period resulted in increased muscle strength, a dramatic reduction in cardiac size, relief of cardiomyopathy, partial repletion of carnitin levels in plasma and muscle, and complete repletions in the liver.

The syndrome of systemic carnitine deficiency

Ketogenesis was impaired on a high fat diet, but omega oxidation of fatty acids was enhanced, and oral replacement therapy restored plasma carnitine levels to normal, but not liver or muscle carnite levels, and was accompanied by clinical improvement.

Carnitine Status at Birth of Newborn Infants of Varying Gestation

Both plasma and red blood cell concentrations of carnitine in cord blood samples from preterm and term Neonates were significantly higher in preterm than in term neonates, and both were particularly elevated in extremely immature neonates.

Action of carnitine on long chain fatty acid oxidation by liver.

  • I. Fritz
  • Biology
    The American journal of physiology
  • 1959
The addition of dl-carnitine to various types of particulate liver preparations resulted in augmented oxidation of labeled palmitate and stearate. In contrast, carnitine exerted little if any effec...