L-carnitine attenuates the development of kidney fibrosis in hypertensive rats by upregulating PPAR-γ.

@article{Zambrano2014LcarnitineAT,
  title={L-carnitine attenuates the development of kidney fibrosis in hypertensive rats by upregulating PPAR-γ.},
  author={Sonia Zambrano and Antonio Jes{\'u}s Blanca and Mar{\'i}a Victoria Ruiz-Armenta and Jos{\'e} Luis Miguel-Carrasco and M. C. Rodr{\'i}guez Ar{\'e}valo and Alfonso Mate and Carmen Mar{\'i}a V{\'a}zquez},
  journal={American journal of hypertension},
  year={2014},
  volume={27 3},
  pages={460-70}
}
BACKGROUND The development of renal fibrosis is a consequence of arterial hypertension. L-carnitine plays an essential role in the β-oxidation of fatty acids, and we have previously demonstrated hypotensive, antioxidant, and anti-inflammatory effects of L-carnitine in arterial hypertension. This work aims to analyze the effect of L-carnitine on renal fibrosis and to explore the participation of peroxisome-proliferator activated receptor (PPAR)-γ in this effect. METHODS Four groups or rats… CONTINUE READING

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Hypertension and kidney disease.

Clinical nephrology • 2010
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Highly Influenced

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