L-asparaginase treatment reduces the anticoagulant potential of the protein C system without affecting vitamin K-dependent carboxylation.

@article{ViganoDAngelo1990LasparaginaseTR,
  title={L-asparaginase treatment reduces the anticoagulant potential of the protein C system without affecting vitamin K-dependent carboxylation.},
  author={S. Vigano'D'Angelo and Luigi Gugliotta and M Mattioli Belmonte and M L Cascione and Elisabetta Pattarini and Armando D'angelo},
  journal={Thrombosis research},
  year={1990},
  volume={59 6},
  pages={985-94}
}
The changes in plasma levels of the vitamin K-dependent natural anticoagulants protein C (PC) and protein S (PS) and procoagulant factors II, IX and X were evaluated in 8 adult patients during treatment with L-asparaginase (L-ase i.v. 120,000 U/m2 over 10 days). PC anticoagulant activity and factor IX, X and II coagulant activity decreased proportionally to their half-lives to a nadir of 50-60% of pretreatment values after 2-5 L-ase infusions, suggesting that inhibition of protein synthesis… CONTINUE READING