L-asparaginase treatment in acute lymphoblastic leukemia: a focus on Erwinia asparaginase.

@article{Pieters2011LasparaginaseTI,
  title={L-asparaginase treatment in acute lymphoblastic leukemia: a focus on Erwinia asparaginase.},
  author={Rob Pieters and Stephen P Hunger and Joachim Boos and Carmelo Rizzari and Lewis B. Silverman and Andr{\'e} Baruchel and Nicola Goekbuget and Martin Schrappe and Ching-Hon Pui},
  journal={Cancer},
  year={2011},
  volume={117 2},
  pages={238-49}
}
Asparaginases are a cornerstone of treatment protocols for acute lymphoblastic leukemia (ALL) and are used for remission induction and intensification treatment in all pediatric regimens and in the majority of adult treatment protocols. Extensive clinical data have shown that intensive asparaginase treatment improves clinical outcomes in childhood ALL. Three asparaginase preparations are available: the native asparaginase derived from Escherichia coli (E. coli asparaginase), a pegylated form of… CONTINUE READING
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