L-arginine uptake and metabolism by lung macrophages and neutrophils following intratracheal instillation of silica in vivo.

@article{Schapira1998LarginineUA,
  title={L-arginine uptake and metabolism by lung macrophages and neutrophils following intratracheal instillation of silica in vivo.},
  author={Ralph M. Schapira and John H. Wiessner and James F Morrisey and Urias A Almagro and L D Nelin},
  journal={American journal of respiratory cell and molecular biology},
  year={1998},
  volume={19 2},
  pages={308-15}
}
Nitric oxide (NO) has been associated with lung inflammation following exposure to silica. L-arginine can be converted to NO and L-citrulline by nitric oxide synthase (NOS), or into urea and L-ornithine by arginase. We tested the hypothesis that after instillation of silica into rat lungs in vivo, lung inflammatory cells increase L-arginine metabolism by both NOS and arginase, which is associated with an increase in L-arginine uptake. We isolated lung inflammatory cells 3 d after silica or… CONTINUE READING
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