L-arginine potentiates excitatory amino acid-induced seizures elicited in the deep prepiriform cortex.

@article{Sarro1993LargininePE,
  title={L-arginine potentiates excitatory amino acid-induced seizures elicited in the deep prepiriform cortex.},
  author={Giovambattista De Sarro and Eugenio Donato Di Paola and Mª Jes{\'u}s Merayo Vidal},
  journal={European journal of pharmacology},
  year={1993},
  volume={230 2},
  pages={
          151-8
        }
}
Microinjection of N-methyl-D-aspartate (NMDA; 1 and 2.5 nmol) or kainate (KA; 50 pmol) into the deep prepiriform cortex elicited behavioral signs of seizure activity. No epileptiform activity was observed after deep prepiriform cortex microinjection of either L-arginine (L-Arg, 5 and 10 nmol) or its D-enantiomer, D-arginine (D-Arg, 2.5-10 nmol). However, both the seizure score and the incidence of electroencephalographic (EEG) epileptic discharges elicited by NMDA (1 and 2.5 nmol) and KA (50… CONTINUE READING
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