L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits.

@article{Rossitch1991LarginineNE,
  title={L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits.},
  author={Eugene Rossitch and Elaine Alexander and Peter M. Black and John P Cooke},
  journal={The Journal of clinical investigation},
  year={1991},
  volume={87 4},
  pages={
          1295-9
        }
}
We hypothesized that normal vascular reactivity could be restored in vessels from hypercholesterolemic animals by exposing them to L-arginine, the precursor of endothelium-derived relaxing factor (EDRF). Basilar arteries were harvested from New Zealand white rabbits fed normal chow or that supplemented with 2% cholesterol for 10 wk. Vessels were cannulated for perfusion at physiologic pressure. Changes in vessel diameter were monitored by videomicroscopy. In comparison to normal vessels, those… CONTINUE READING

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