L-arginine minimizes reperfusion injury in a low-flow, reflow model of liver perfusion.

@article{Jones1996LarginineMR,
  title={L-arginine minimizes reperfusion injury in a low-flow, reflow model of liver perfusion.},
  author={Steven M. Jones and Ronald G. Thurman},
  journal={Hepatology},
  year={1996},
  volume={24 1},
  pages={163-8}
}
A low-flow, reflow model of liver perfusion was used in the rat to investigate the effects of L-arginine on reperfusion injury in the absence of blood elements. In contrast to in vivo studies, L-arginine cannot minimize hypoxia by improving the microcirculation under these special conditions, but rather can only increase oxygen delivery upon reflow. During reflow, lactate dehydrogenase (LDH) release reached a new steady-state value of 35 +/- 3 U/g/h in livers perfused in the absence of L… CONTINUE READING

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