L-arginine metabolism during interaction of Trypanosoma cruzi with host cells.

  title={L-arginine metabolism during interaction of Trypanosoma cruzi with host cells.},
  author={Gonzalo Peluffo and Luc{\'i}a Piacenza and Florencia Irigo{\'i}n and Mar{\'i}a Noel {\'A}lvarez and Rafael Radi},
  journal={Trends in parasitology},
  volume={20 8},
Trypanosoma cruzi invades a diversity of nucleated cells in the mammalian host. Macrophages are among the first cells to be parasitized and, after activation by inflammatory stimuli, they participate in the control of infection. However, some parasites manage to evade the immune response and establish a chronic infection in differentiated cells. L-arginine is located at the crossroads of divergent routes that produce metabolites, including nitric oxide and polyamines, which influence the… CONTINUE READING

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