L-arginine infusion decreases platelet aggregation through an intraplatelet nitric oxide release.

Abstract

Nitric Oxide (NO) inhibits platelet aggregation via activation of an intraplatelet soluble guanylate cyclase which induces an increase in cyclic GMP (1). It has been also demonstrated that platelets contain a constitutive, calcium-dependent, NO synthase which is activated by collagen-induced platelet aggregation. This leads to a NO synthesis from L-Arginine… (More)

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Cite this paper

@article{Marietta1997LarginineID, title={L-arginine infusion decreases platelet aggregation through an intraplatelet nitric oxide release.}, author={Marco Marietta and Fabrizio Facchinetti and I. Neri and Fernando Piccinini and Anthony R. Volpe and Giuseppe Torelli}, journal={Thrombosis research}, year={1997}, volume={88 2}, pages={229-35} }