L-arginine improves the symptoms of strokelike episodes in MELAS.

  title={L-arginine improves the symptoms of strokelike episodes in MELAS.},
  author={Yasutoshi Koga and Yukihiro Akita and Junko Nishioka and Shuichi Yatsuga and Nataliya Povalko and Yuko Tanabe and Shinji Fujimoto and Toyojiro Matsuishi},
  volume={64 4},
Based on the hypothesis that mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS) are caused by impaired vasodilation in an intracerebral artery, the authors evaluated the effects of administering l-arginine, a nitric oxide precursor. Patients were administered L-arginine intravenously at the acute phase or orally at the interictal phase. L-arginine infusions significantly improved all strokelike symptoms, suggesting that oral administration within 30 minutes… CONTINUE READING
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