L-arginine improves endothelial vasoreactivity and reduces thrombogenicity after thrombolysis in experimental deep venous thrombosis.

@article{Lin2003LarginineIE,
  title={L-arginine improves endothelial vasoreactivity and reduces thrombogenicity after thrombolysis in experimental deep venous thrombosis.},
  author={Peter H Lin and Chris Johnson and Jennifer K. Pullium and Ruth Lee Bush and Brian S. Conklin and Changyi Johnny Chen and Alan B. Lumsden},
  journal={Journal of vascular surgery},
  year={2003},
  volume={38 6},
  pages={1396-403}
}
PURPOSE Nitric oxide (NO) is important in regulation of platelet aggregation, endothelial function, and intravascular thrombosis. The purposes of this study were to assess the effect of thrombolysis on endothelial function in a porcine model of deep venous thrombosis (DVT) and to evaluate the effect of NO precursor l-arginine on endothelial function after thrombolytic therapy. METHODS DVT was created in bilateral iliac veins by deploying a self-expanding stent-graft that incorporated an… CONTINUE READING