L-arginine-dependent nitric oxide synthase: a new metabolic pathway in the lung and airways.

  title={L-arginine-dependent nitric oxide synthase: a new metabolic pathway in the lung and airways.},
  author={Philippe Jorens and Paul A. Vermeire and Arnold G. Herman},
  journal={The European respiratory journal},
  volume={6 2},
An L-arginine-dependent pathway, metabolising L-arginine to citrulline and nitrogen oxides, has been described in many cell types in different species, including man. Two subtypes of this nitric oxide synthase have been reported: a constitutive enzyme type, releasing nitric oxide after stimulation, is typically found in endothelial and neural cells; another subtype can be induced in macrophages after cytokine treatment. This review summarizes the literature on the known and proposed roles of… CONTINUE READING
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