L-arginine deficiency causes airway hyperresponsiveness after the late asthmatic reaction.

@article{Maarsingh2009LarginineDC,
  title={L-arginine deficiency causes airway hyperresponsiveness after the late asthmatic reaction.},
  author={Harm Maarsingh and B E Bossenga and I. Sophie T. Bos and Haukeline H. Volders and Johan Zaagsma and Herman Meurs},
  journal={The European respiratory journal},
  year={2009},
  volume={34 1},
  pages={191-9}
}
Peroxynitrite has been shown to be crucially involved in airway hyperresponsiveness (AHR) after the late asthmatic reaction (LAR). Peroxynitrite production may result from simultaneous synthesis of nitric oxide (NO) and superoxide by inducible NO-synthase (iNOS) at low L-arginine concentrations. L-arginine availability to iNOS is regulated by its cellular uptake, which can be inhibited by eosinophil-derived polycations and by arginase, which competes with iNOS for the common substrate. Using a… CONTINUE READING

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