L-arginine/nitric oxide pathway and interaction with lead acetate on rat submandibular gland function.

@article{Abdollahi2000LargininenitricOP,
  title={L-arginine/nitric oxide pathway and interaction with lead acetate on rat submandibular gland function.},
  author={Mohammad Abdollahi and Ahmad Raza Dehpour and F Shafayee},
  journal={Pharmacology & toxicology},
  year={2000},
  volume={87 5},
  pages={198-203}
}
The effects of lead acetate, L-arginine (nitric oxide precursor) and L-NAME (nitric oxide synthesis inhibitor) on rat submandibular secretory function were studied. Pure submandibular saliva was collected intraorally from anaesthetized rats by a micro polyethylene cannula using pilocarpine as secretagogue. Treatment for twenty-eight days with three doses of lead acetate (0.01%, 0.04%, 0.05% w/v) in drinking water caused significant alterations on salivary function. Salivary flow rate was… CONTINUE READING
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