L-Type Ca(2+) channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons.

@article{Rajadhyaksha1999LTypeCC,
  title={L-Type Ca(2+) channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons.},
  author={Anjali M Rajadhyaksha and Amy K. Barczak and Wendy Mac{\'i}as and J C Leveque and Samuel E. Lewis and Christine Konradi},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 15},
  pages={6348-59}
}
The second messenger pathways linking receptor activation at the membrane to changes in the nucleus are just beginning to be unraveled in neurons. The work presented here attempts to identify in striatal neurons the pathways that mediate cAMP response element-binding protein (CREB) phosphorylation and gene expression in response to NMDA receptor activation. We investigated the phosphorylation of the transcription factor CREB, the expression of the immediate early gene c-fos, and the induction… CONTINUE READING
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Electrophysiological studies of NMDA receptors

  • P Ascher, L Nowak
  • Trends Neurosci
  • 1987
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