L-Serine: a Naturally-Occurring Amino Acid with Therapeutic Potential

@article{Metcalf2017LSerineAN,
  title={L-Serine: a Naturally-Occurring Amino Acid with Therapeutic Potential},
  author={J. Metcalf and R. Dunlop and J. Powell and S. Banack and P. Cox},
  journal={Neurotoxicity Research},
  year={2017},
  volume={33},
  pages={213-221}
}
In human neuroblastoma cell cultures, non-human primates and human beings, L-serine is neuroprotective, acting through a variety of biochemical and molecular mechanisms. Although L-serine is generally classified as a non-essential amino acid, it is probably more appropriate to term it as a “conditional non-essential amino acid” since, under certain circumstances, vertebrates cannot synthesize it in sufficient quantities to meet necessary cellular demands. L-serine is biosynthesized in the… Expand
Mechanisms of l-Serine Neuroprotection in vitro Include ER Proteostasis Regulation
TLDR
It is proposed that l-serine may be functioning as a small proteostasis regulator, in effect altering the cells to quickly respond to a possible oxidative insult, thus favoring a return to homeostasis. Expand
Mechanisms of l-Serine-Mediated Neuroprotection Include Selective Activation of Lysosomal Cathepsins B and L
TLDR
Activation of autophagic-lysosomal proteolysis may contribute to the neuroprotective effect of l -serine, which has been reported in cell culture and human clinical trials. Expand
L‐serine: a neglected amino acid with a potential therapeutic role in diabetes
TLDR
It is believed that L‐serine should be considered as an emerging therapeutic option in diabetes, although work remains in order to fully understand the role of L‐Serine in diabetes. Expand
L-Serine, an Endogenous Amino Acid, Is a Potential Neuroprotective Agent for Neurological Disease and Injury
  • Lisha Ye, Yechao Sun, Zhenglin Jiang, Guohua Wang
  • Frontiers in Molecular Neuroscience
  • 2021
Central nervous system (CNS) lesions are major causes of human death and disability worldwide, and they cause different extents of motor and sensory dysfunction in patients. Thus, it is crucial toExpand
Evaluating amino acids as protectants against β-N-methylamino-l-alanine-induced developmental neurotoxicity in a rat model.
TLDR
The protective value of l-serine, l-phenylalanine and l-alanine is determined in reducing the effects of neonatal exposure to BMAA in a Sprague Dawley rat model, suggesting that competitive amino acid uptake plays a minor role in protecting against BMAA-induced neurotoxicity. Expand
Investigating β-N-Methylamino-l-alanine Misincorporation in Human Cell Cultures: A Comparative Study with Known Amino Acid Analogues
TLDR
The results show that BMAA is not misincorporated into human proteins and that misincorporation is not a valid mechanism of toxicity. Expand
Amino acids in the regulation of aging and aging-related diseases
TLDR
Much more research is needed to understand the signaling pathways activated by amino acid imbalance before efficacious and well-tolerated dietary interventions can be developed for human aging and aging-related disorders. Expand
The Intersection of Serine Metabolism and Cellular Dysfunction in Retinal Degeneration
TLDR
This review provides a strong argument for the exploration of serine-based clinical interventions for retinal pathologies by emphasizing how and why the de novo production and demand for serine is exceptionally elevated in the retina. Expand
3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment.
TLDR
The role ofPHGDH in various cancers and inhibitors that have recently been identified to highlight progression in cancer treatment are described and the design and development of novel PHGDH inhibitors may have broad implications for cancer treatment. Expand
Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase.
TLDR
Azacoccone E, an aza-epicoccone derivative from the culture of Aspergillus flavipes, exhibited effective inhibitory activity againstPHGDH in vitro and can be considered as a possible drug candidate targeting at PHGDH for treatment of cancers. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 113 REFERENCES
L-serine in disease and development.
TLDR
Recent insights into the role of L-serine and the pathways of L -serine utilization in disease and during development are reviewed, in particular of the central nervous system. Expand
Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission.
TLDR
Cloning and expression of serine racemase in the brain demonstrates the conservation of D-amino acid metabolism in mammals with implications for the regulation of N-methyl-D-aspartate neurotransmission through glia-neuronal interactions. Expand
d-Serine: The right or wrong isoform?
TLDR
The findings implying an important role for d-serine in human physiology and pathology and pathology (excitotoxicity, perinatal asphyxia, amyotrophic lateral sclerosis, Alzheimer's disease, epilepsy, schizophrenia and bipolar disorder), and clinical applications derived from these results are discussed. Expand
Analysis of free D-serine in mammals and its biological relevance.
  • T. Nishikawa
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2011
TLDR
The views that the signaling system of endogenous free D-serine plays important roles, at least, through the action on the NMDA receptors in the brain wiring development and the regulation of higher brain functions, including cognitive, emotional and sensorimotor function are supported. Expand
Resurgence of Serine: An Often Neglected but Indispensable Amino Acid*
TLDR
Recent information regarding the synthesis of serine and the regulation of its metabolism is reviewed and the role played by phosphoenolpyruvate carboxykinase is discussed. Expand
Novel neuroglial and glioglial relationships mediated by L-serine metabolism.
TLDR
It is proposed that L-serine synthesis in these glial cells and its supply to nearby neurons and other glia constitute a novel metabolic unit in the brain. Expand
The natural non-protein amino acid N-β-methylamino-l-alanine (BMAA) is incorporated into protein during synthesis
TLDR
It is reported that BMAA incorporates into protein as an error in synthesis when a template DNA sequence is used and also associated with proteins through non-covalent bonding. Expand
Roles of l-serine and sphingolipid synthesis in brain development and neuronal survival.
TLDR
The metabolic system that coordinates sphingolipid synthesis with the l-serine synthetic pathway between neurons and glia is discussed and the crucial roles of the metabolic conversion of l-Serine to sphingoipids in neuronal development and survival are discussed. Expand
Serine biosynthesis and transport defects.
  • A. El-Hattab
  • Medicine, Biology
  • Molecular genetics and metabolism
  • 2016
TLDR
L-serine therapy may be beneficial in preventing or ameliorating symptoms in serine biosynthesis and transport defects, if started before neurological damage occurs, and the potential role of serine therapy is reviewed. Expand
Synthesis and release of L‐serine by rat astroglia‐rich primary cultures
TLDR
The enzymes of the “phosphorylated pathway” of serine biosynthesis, i.e., 3‐phosphoglycerate dehydrogenase, phosphoserine aminotransferase andosphoserine phosphatase are present in rat brain as well as in rat astroglia‐rich primary cultures and their specific activities have been determined. Expand
...
1
2
3
4
5
...