L-Selectin Shedding Does Not Regulate Constitutive T Cell Trafficking but Controls the Migration Pathways of Antigen-activated T Lymphocytes

@article{Galkina2003LSelectinSD,
  title={L-Selectin Shedding Does Not Regulate Constitutive T Cell Trafficking but Controls the Migration Pathways of Antigen-activated T Lymphocytes},
  author={Elena Galkina and Kyriakos Tanousis and Graham Preece and Mauro Tolaini and Dimitris Kioussis and Oliver Florey and Dorian O. Haskard and Thomas F. Tedder and Ann Ager},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={198},
  pages={1323 - 1335}
}
L-selectin mediates rolling of lymphocytes in high endothelial venules (HEVs) of peripheral lymph nodes (PLNs). Cross-linking of L-selectin causes proteolytic shedding of its ectodomain, the physiological significance of which is unknown. To determine whether L-selectin shedding regulates lymphocyte migration, a mutant form that resists shedding (LdDeltaP-selectin) was engineered. Transgenic mice expressing either LDeltaP or wild-type (WT) L-selectin on T cells were crossed with L-selectin… CONTINUE READING

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