L-Propionyl-carnitine protection of mitochondria in ischemic rat hearts

  title={L-Propionyl-carnitine protection of mitochondria in ischemic rat hearts},
  author={Fabio Di Lisa and Roberta Menab{\`o} and Noris Siliprandi},
  journal={Molecular and Cellular Biochemistry},
The energy-linked processes (transmembrane potential and oxidative phosphorylation) resulted in impaired mitochondria isolated from ischemic perfused rat hearts. Addition of 1.5 mM L-propionyl-carnitine to the perfusate significantly reduced the ischemic damage and ameliorated mitochondrial Ca2+ homeostasis. In both normoxic and ischemic hearts perfused with L-propionyl-carnitine a consistent amount of propionyl-CoA —otherwise undetectable — was produced. L-propionyl-carnitine treatment also… CONTINUE READING


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