L-Propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector

  title={L-Propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector},
  author={Angelo Vanella and Annamaria Russo and Rosaria Acquaviva and Agata Campisi and Claudia Di Giacomo and Valeria Sorrenti and Maria Luisa Barcellona},
  journal={Cell Biology and Toxicology},
L-Propionylcarnitine, a propionyl ester of L-carnitine, increases the intracellular pool of L-carnitine. It exhibits a high affinity for the enzyme carnitine acetyltransferase (CAT) and, thus, is readily converted into propionyl-coenzyme A and free carnitine. It has been reported that L-propionylcarnitine possesses a protective action against heart ischemia–reperfusion injury; however, the antioxidant mechanism is not yet clear. L-Propionylcarnitine might reduce the hydroxyl radical production… CONTINUE READING