L-Proline anchored multicomponent synthesis of novel pyrido[2,3-a]carbazoles; investigation of in vitro antimicrobial, antioxidant, cytotoxicity and structure activity relationship studies.

@article{Indumathi2011LProlineAM,
  title={L-Proline anchored multicomponent synthesis of novel pyrido[2,3-a]carbazoles; investigation of in vitro antimicrobial, antioxidant, cytotoxicity and structure activity relationship studies.},
  author={Thangavel Indumathi and V S Jamal Ahamed and Surk-Sik Moon and Frank R Fronczek and Karnam Jayarampillai Rajendra Prasad},
  journal={European journal of medicinal chemistry},
  year={2011},
  volume={46 11},
  pages={5580-90}
}
The newly synthesized pyrido[2,3-a]carbazoles were prepared in good yields by multicomponent reactions under L-proline as promoter and structurally characterized. Few compounds showed significant activity toward both gram-positive, gram-negative bacterial strains. All compounds exerted negative efficacy for antifungal activity except compounds 5f and 7f which showed moderate activity. All compounds showed weak to moderate capacity for scavenging DPPH. The cytotoxicity was evaluated by… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…