L-Pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases.

@article{Dodt2000LPipecolicAO,
  title={L-Pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases.},
  author={Gabriele Dodt and Dong Gwan Kim and Sylvia A. Reimann and Bernadette E. Reuber and Kathleen McCabe and Stephen J. Gould and Stephanie J. Mihalik},
  journal={The Biochemical journal},
  year={2000},
  volume={345 Pt 3},
  pages={487-94}
}
L-Pipecolic acid oxidase activity is deficient in patients with peroxisome biogenesis disorders (PBDs). Because its role, if any, in these disorders is unknown, we cloned the associated human gene and expressed its protein product. The cDNA was cloned with the use of a reverse genetics approach based on the amino acid sequence obtained from purified L-pipecolic acid oxidase from monkey. The complete cDNA, obtained by conventional library screening and 5' rapid amplification of cDNA ends… CONTINUE READING