L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway.

@article{Kristiansen2014LOrnithinePR,
  title={L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway.},
  author={Rune Gangs\oy Kristiansen and Christopher F Rose and Ole-Martin Fuskev{\aa}g and Hanne K. M{\ae}hre and Arthur Revhaug and Rajiv Jalan and Lars M Ytreb\o},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2014},
  volume={307 10},
  pages={G1024-31}
}
Glycine is an important ammoniagenic amino acid, which is increased in acute liver failure (ALF). We have previously shown that L-ornithine phenylacetate (OP) attenuates ammonia rise and intracranial pressure in pigs suffering from ALF but failed to demonstrate a stoichiometric relationship between change in plasma ammonia levels and excretion of phenylacetylglutamine in urine. The aim was to investigate the impact of OP treatment on the phenylacetylglycine pathway as an alternative and… CONTINUE READING

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