L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis.

  title={L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis.},
  author={John R. Fozard and M L Part and N. J. Prakash and Jeffrey Grove and Paul J. Schechter and Albert Sjoerdsma and J Koch-weser},
  volume={208 4443},
The highly selective, enzyme-activated, irreversible inhibitor of L-ornithine decarboxylase, DL-alpha-difluoromethylornithine, suppresses the increase in uterine L-ornithine decarboxylase activity associated with early embryogenesis in the mouse and arrests embryonic development at that stage. Contragestational effects were confirmed in the rat and rabbit. An increase in L-ornithine decarboxylase activity that leads to a rapid increase in putrescine concentration appears to be essential during… CONTINUE READING
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