L-Ornithine Derived Polyamines in Cystic Fibrosis Airways

  title={L-Ornithine Derived Polyamines in Cystic Fibrosis Airways},
  author={Hartmut Grasemann and Darakhshanda Shehnaz and Masahiro Enomoto and Michael Leadley and Jaques Belik and Felix A Ratjen},
  booktitle={PloS one},
Increased arginase activity contributes to airway nitric oxide (NO) deficiency in cystic fibrosis (CF). Whether down-stream products of arginase activity contribute to CF lung disease is currently unknown. The objective of this study was to test whether L-ornithine derived polyamines are present in CF airways and contribute to airway pathophysiology. Polyamine concentrations were measured in sputum of patients with CF and in healthy controls, using liquid chromatography-tandem mass spectrometry… CONTINUE READING
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The polyamine spermine is increased in cystic fibrosis airway secretions

  • H Grasemann, D Shehnaz, P Pencharz, F Ratjen
  • European Respiratory Journal 38,
  • 2011
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