L-NAME, a nitric oxide synthase inhibitor, modulates cholinergic antinociception.

@article{Jain1999LNAMEAN,
  title={L-NAME, a nitric oxide synthase inhibitor, modulates cholinergic antinociception.},
  author={Naveen K. Jain and S. K. Kulkarni},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1999},
  volume={21 3},
  pages={161-5}
}
Systemic administration of sumatriptan and buspirone (20 mg/kg: 5-HT1A agonists) produced antinociception against acetic acid-induced writhing. The antinociceptive effect was potentiated by cholinomimetic physostigmine (0.05 mg/kg i.p.) and blocked by the muscarinic antagonist atropine (5 mg/kg i.p.). Naloxone, an opiate antagonist, failed to reverse the sumatriptan- or buspirone-induced antinociception, but pindolol (10 mg/kg), a nonselective 5-HT1A antagonist, blocked this response… CONTINUE READING