L-N-Acetylcysteine protects against radiation-induced apoptosis in a cochlear cell line.

  title={L-N-Acetylcysteine protects against radiation-induced apoptosis in a cochlear cell line.},
  author={Wong Kein Low and Li Sun and Michelle G. K. Tan and Alvin Chua and De-yun Wang},
  journal={Acta oto-laryngologica},
  volume={128 4},
CONCLUSION L-N-Acetylcysteine (L-NAC) significantly reduced reactive oxygen species (ROS) generation and cochlear cell apoptosis after irradiation. The safe and effective use of L-NAC in reducing radiation-induced sensorineural hearing loss (SNHL) should be verified by further in vivo studies. OBJECTIVES Radiation-induced SNHL is a common complication after radiotherapy of head and neck tumours. There is growing evidence to suggest that ROS play an important role in apoptotic cochlear cell… CONTINUE READING


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