L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough.

@article{Yamaguchi2012LMPZAN,
  title={L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough.},
  author={Yoshihide Yamaguchi and Akiko Hayashi and Celia W. Campagnoni and Akio Kimura and Takashi Inuzuka and Hiroko Baba},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 21},
  pages={
          17765-76
        }
}
Myelin protein zero (P0 or MPZ) is a major myelin protein (∼30 kDa) expressed in the peripheral nervous system (PNS) in terrestrial vertebrates. Several groups have detected a P0-related 36-kDa (or 35-kDa) protein that is expressed in the PNS as an antigen for the serum IgG of patients with neuropathy. The molecular structure and function of this 36-kDa protein are, however, still unknown. We hypothesized that the 36-kDa protein may be derived from P0 mRNA by stop codon readthrough. We found a… CONTINUE READING

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