L-Histidinol attenuates Fanconi syndrome induced by ifosfamide in rats.

  title={L-Histidinol attenuates Fanconi syndrome induced by ifosfamide in rats.},
  author={Osama Ahmed Badary},
  journal={Experimental nephrology},
  volume={7 4},
The effect of L-histidinol (LHL), a structural analogue of the essential amino acid L-histidine, on ifosfamide (IFO) induced nephrotoxicity was investigated in the rat. The aim of this study was to assess whether oral supplementation of LHL could attenuate Fanconi syndrome (FS) induced by IFO. Male Wistar albino rats received daily injections of IFO (50 mg/kg) for 5 days with or without oral supplementation of 0.5% LHL in the drinking water. LHL was supplemented for 3 days before IFO… CONTINUE READING
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