L-DOPA-induced dyskinesia in a rat model of Parkinson's disease is associated with the fluctuational release of norepinephrine in the sensorimotor striatum.

@article{Wang2014LDOPAinducedDI,
  title={L-DOPA-induced dyskinesia in a rat model of Parkinson's disease is associated with the fluctuational release of norepinephrine in the sensorimotor striatum.},
  author={Yong Wang and Hui Wang and Tao Wang and Chen Huang and Jian Liu Q Liu},
  journal={Journal of neuroscience research},
  year={2014},
  volume={92 12},
  pages={
          1733-45
        }
}
L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) is the most common complication of standard L-DOPA therapy for Parkinson's disease experienced by most parkinsonian patients. LID is associated with disruption of dopaminergic homeostasis in basal ganglia following L-DOPA administration. Norepinephrine (NE) is another important catecholaminergic neurotransmitter that is also believed to be involved in the pathogenesis of LID. This study compared NE release in the ipsilateral… CONTINUE READING

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The Rat Brain in Stereotaxic Coordinates

Trends in Neurosciences • 1984
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